P08 Jung, Stecher

The role of primary metabolites in the intestinal ecosystem under normal and inflamed conditions

Principal Investigators:
Jung, Kirsten, LMU
Stecher, Barbara, LMU

Inflammatory processes create metabolic and trophic niches in the gut that, in turn, affect the composition and function of the microbial ecosystem. The project P08 will investigate the role of primary luminal metabolites, specifically pyruvate, and characterize the impact of pyruvate sensing and uptake on fitness and growth of Salmonella and the individual species of the microbiota using germ-free or gnotobiotic mice colonized with the minimal bacterial consortium Oligo-MM and other mouse models of gut inflammation.