P14 Clavel, Stecher

Targeted design and manipulation of minimal bacterial consortia for microbial ecology of bile acid metabolism

Principal Investigators:
Clavel, Thomas, RWTH
Stecher, Barbara, LMU

In P14 we study the diversity of mouse intestinal bacteria involved in secondary bile acid production and investigate their impact on the host using targeted experimental models. We will establish simplified communities of cultured bacteria from the mouse gut and manipulate them in targeted manners to dissect microbe-microbe and microbe-host interactions underlying bile acid conversion both in vitro and in vivo. Thereby, we will test the causal role of secondary bile acids in gnotobiotic disease models available in this CRC.