Z01 Bleich, Clavel, Haller
Gnotobiotic mouse models and minimal bacterial consortia
Germ-free animals can be utilized to unravel the functionality of individual murine or human bacterial species, synthetic consortia or human fecal transplants in health and disease, implementing highly defined experimental conditions. In this core project, the two well-established facilities at TUM (PI Haller) and Hannover (PI Bleich) generate and maintain gnotobiotic mice. This expertise will be complemented by anaerobic bacterial cultivation techniques (PI Clavel) with the aim of tailoring novel bacterial consortia that are adapted to the specific needs of consortium members and to their implementation in gnotobiotic models.