Impact of Desulfovibrio spp. and sulfur metabolism on the pathogenesis of chronic intestinal inflammation and colitis-associated cancer
Desulfovibrio spp. in the human digestive tract can use sulfate to create hydrogen sulfide (H2S). While endogenous H2S is an important signal transducer in human cells, elevated exposure may induce aberrant tissue responses, including oxidative stress, genotoxicity and loss of epithelial barrier integrity. In this project, we will address the causal role of Desulfovibrio and their sulfur metabolism in the pathogenesis of colitis and colitis-associated cancer.